Distributed adaptive tracking control for multi-agent systems with uncertain dynamics

Nonlinear Dynamics - In this paper, we investigate a general integrable three-component coupled nonlocal nonlinear Schrödinger system with the parity-time symmetry. The general Nth Darboux...     

DNA水凝胶在生物传感中的应用和发展

脱氧核糖核酸(DNA)是一种重要的生物分子,具有许多独特的性质如:信息传递、分子识别、可编辑等。DNA水凝胶同时具有DNA分子和水凝胶材料的优势,并且可以引入其他纳米材料获得多功能杂化水凝胶。相比于传统水凝胶,DNA水凝胶具有良好的特异识别能力以及可以按需设计的性质,从而被广泛应用于生物传感领域。本文围绕DNA水凝胶的合成、响应机制以及在传感领域的应用进行综述。按照不同的合成方法可分为线性DNA链缠绕水凝胶、枝状DNA自组装水凝胶、杂合DNA水凝胶。根据传感机制的不同又可以分为包埋封装法和非包埋封装法,包埋封装发法又分为:酶的包埋释放、抗原-抗体的包埋释放、纳米材料的包埋释放。本文总结了近几年DNA水凝胶在重金属离子检测、核酸检测、葡萄糖检测、蛋白质和代谢小分子检测,以及细胞检测等热门领域的研究情况,最后对其未来的发展进行了展望。     

混沌实验教学之路

混沌电路实验包括非线性元件如电阻或电感的选择、电路构建与波形的分析、混沌吸引子显示与模拟等内容,采用分立元件与学生自组的实验方案,坚持实验过程与理论分析相结合,是一个颇有趣味的非线性物理实验.     

Sign patterns that allow diagonalizability revisited

Characterization of sign patterns that allow diagonalizability has been a long-standing open problem. In this article, necessary and sufficient conditions for a sign pattern to allow diagonalizability are obtained, in terms of allowing related properties. Some properties of normal sign patterns are considered. In particular, it is shown that normal sign patterns of order up to 3 allow diagonalizability. Two combinatorial necessary conditions for a sign pattern to allow diagonalizability are also presented.     

Design and application of feedback-sustained target waves in excitable medium

In this paper, we present a formulas of rational ratios between the frequency of external stimulus and its paced target waves, considering the existence of the absolute refractory period and the relative refractory period. Based on this, we design a self-sustained high-frequency target waves by feeding back few periphery field points to the center to responsibly play the role of source for pacemaker. Such constructed target waves, to all appearances, are shown as a repetition of their initial condition. We explore further in application that those feedback-sustained targets can eliminate both a freely rotating spiral waves and a pinned ones only if frequencies, feedback lengths and radius of obstacles are appropriately chosen. After feedback stimuli are removed, the system eventually returns to the rest state.     

抗肿瘤缺氧诱导因子-1的小分子抑制剂

肿瘤的缺氧微环境与其增殖、分化、血管生成、能量代谢、耐药性的发生以及患者预后状况密切相关。缺氧诱导因子1(Hypoxia-inducible factor 1, HIF-1)是细胞适应缺氧环境的重要转录因子和调控蛋白,通过调控下游靶基因如EPO、VEGF、GLUT等的表达,促进血管新生及有氧糖酵解以适应缺氧的环境,进而影响肿瘤细胞代谢、血管生成和肿瘤转移等。因此,开发以HIF-1为靶标的小分子抑制剂药物有望成为一种有效的肿瘤治疗方法。本文就HIF-1小分子抑制剂在肿瘤学研究中的进展进行综述,旨在为靶向HIF-1抗肿瘤药物的研发提供新思路。     

K3PO4 promoted dipolar [3+3] cyclization: Direct synthesis of pyrazino[2,1-a]isoquinoline derivatives

A K₃PO₄ promoted dipolar [3+3] cyclization of dihydroisoquinoline imines and arylacyl bromides has been developed. This process realized the direct synthesis of pyrazino[2,1-a]isoquinoline derivatives in 44–69% yields. A head to tail dimerization was proposed as key step for this procedure.     

Effect of additives on the structure and electrochemical performance of mesoporous nickel hydroxide

Nickel hydroxide mesoporous structures are synthesized by a simple method in the presence of different additives (oxalic acid, aminoacetic acid, and sulfosalicylic acid). Structural characterizations reveal that the additives can affect the crystal structure, increase the specific surface area, and reduce the pore size of the products. The electrochemical properties of the synthesized Ni(OH)₂ samples are dependent on their crystal phase, surface area, and pore size distribution. Mesoporous β-Ni(OH)₂ with poor crystallinity shows high specific capacitances at different current densities and excellent cycling ability. A highest specific capacitance of 1,693 F?g^?1 can be achieved at a scan rate of 5 mV?s^?1. The results suggest its potential application in electrochemical supercapacitors.     

A tubular one‐dimensional polymer constructed from alternating clusters of europium(III)–water and copper(I) chloride bridged by 4‐(pyridin‐4‐yl)benzoate

A new 3d–4f heterometallic polymer, poly[[aqua‐μ₃‐chlorido‐[μ₃‐4‐(pyridin‐4‐yl)benzoato]tris[μ₂‐4‐(pyridin‐4‐yl)benzoato]dicopper(I)erbium(III)] dihydrate], {[Cu₂Er(C₁₂H₈NO₂)₄Cl(H₂O)]·2H₂O}_n, was synthesized by the hydrothermal reaction of Er₂O₃, CuCl₂·2H₂O and 4‐(pyridin‐4‐yl)benzoic acid in the presence of HClO₄. The asymmetric unit contains one Er³⁺ cation, two Cu⁺ cations, one Cl⁻ anion, four deprotonated 4‐(pyridin‐4‐yl)benzoate ligands, one coordinated aqua ligand and two solvent water molecules. This tubular one‐dimensional polymer is constructed from alternating clusters of europium(III)–water and copper(I) chloride bridged by 4‐(pyridin‐4‐yl)benzoate ligands. Extensive hydrogen‐bonding interactions involving both the coordinated and the solvent water molecules provide further stabilization to the structure.